| 000 | a | ||
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| 999 |
_c17315 _d17315 |
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| 003 | OSt | ||
| 005 | 20220825093037.0 | ||
| 008 | 220825b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_98812 _aJacob, Shery |
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| 245 | _aDose conversion between animals and humans: a practical solution | ||
| 250 | _aVol.56(3), Jul-Sep | ||
| 260 |
_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022 |
||
| 300 | _a600-607p. | ||
| 520 | _aSelecting the most appropriate first-in-human and pharmacologically active dose for any new drugs or biologicals is a crucial step before starting a clinical trial investigation in adult healthy human subjects. Extrapolation of dose between various rodent and non-rodent animal species is critical for biomedical researchers during initial drug development. The objective of this review is to provide practical guidance on how allometric scaling based on the body surface area normalization can be effectively utilized for dose conversion between various animal species. The standard conversion factors are included to allow dose translation between animals to humans and humans to animals expressed either in mg/kg or mg/m2 . The estimation of a safe starting dose is important to ensure the safety and tolerability of humans during phase-I clinical trials. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_917577 _aNair, Anroop B. |
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| 773 | 0 |
_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research |
|
| 856 |
_uhttps://ijper.org/sites/default/files/IndJPhaEdRes-56-3-600.pdf _yClick here |
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| 942 |
_2ddc _cAR |
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