000			a
999			_c17323 _d17323
003			OSt
005			20220825133841.0
008			220825b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_911968 _aSunil Kumar
245			_aFloating microspheres of lafutidine: formulation, optimization, characterization, in-vitro and in-vivo floatability studies using eudragit grades
250			_aVol.56(3), Jul-Sep
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022
300			_a681-688p.
520			_aAim/Background: The objective behind this study was to develop a Microspheres of Lafuditine using central composite design for gastroretentive drug delivery. Materials and Methods: Gastroretentive Microspheres were prepared by Emulsion Solvent Evaporation method. The present investigation will study the effect of formulation variables (polymer concentration etc) on the floating behaviour and drug release characteristics for developing mathematical relationship between them and optimize the formulation with an aim to minimize onset of floatation, maximize the duration of floatation in stomach in order to achieve maximum bioavailability and therapeutic efficacy of selected drug. Microspheres were evaluated for shape, size, melting point, buoyancy time, floating capacity, % yield, swelling index, and in-vitro drug release and in-vivo kinetic studies. Results: Results showed that selected independent variables significantly affect the yield (66-85%), particle size (3.78-10.62 μm), buoyancy (42.68-95.75%), encapsulation efficiency (69.32–94.05%), and cumulative drug release from the microspheres (79.02-96.92%). The interface and quadratic terms were also affect the process variables, it can be said that to develop and optimize gastroretentive system of Lafuditine with central composite design (CCD) is a valuable second-degree design which is effective treatment of H. pylori mediated infection and also provides a base to localize the drug release in the gastric region. Conclusion: The gastroretentive floating Microparticulate system of Lafutidine will enhance the patient compliance and play a vital role in improving patient’s quality of life. Keywords: Lafutidine, Eudragit, Central composite design, In-vitro drug release, Microparticulate system, Sodium bicarbonate.
650		0	_94639 _aPHARMACEUTICS
700			_94645 _aTiwari, Abhishek
773	0		_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-56-3-681.pdf _yClick here
942			_2ddc _cAR