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_c17356 _d17356 |
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| 005 | 20220829110703.0 | ||
| 008 | 220829b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_917649 _aPantwalawalkar, Jidnyasa |
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| 245 | _aFormulation of silk fibroin-based single polymeric floating microspheres for sustained release of lafutidine | ||
| 250 | _aVol.56(2), Apr-June | ||
| 260 |
_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022 |
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| 300 | _a396-404p. | ||
| 520 | _aPurpose: The present study was aimed at the formulation of lafutidine-loaded silk fibroin- based floating microspheres (LAFU-SF-Microspheres) for the site-specific sustained release of the drug. Materials and Methods: Briefly, the single polymeric system comprising SF was selected to prepare LAFU-SF-Microspheres by employing the emulsion solvent evaporation method. Subsequently, the obtained LAFU-SF-Microspheres were assessed for particle size, zeta potential, percent entrapment efficiency (%EE), percentage drug content (%DC), micromeritics, floating profile, in-vitro drug release, spectroscopical analysis, and accelerated stability study. Results: The particle size and zeta potential of the LAFU-SF-Microsphere were found to be 2.3-6.8μm and -21.93mV respectively whilst % EE and % DC of LAFU-SF-Microspheres were found to be 86.83±3.46% and 93.89±3.98% respectively. Moreover, it demonstrated the adequate angle of repose (26.50±1.06°) and Carr’s Compressibility Index (CI) confirming the excellent flow properties. In view of the floating profile, LAFU-SF-Microspheres showed floating lag time (FLT) between 9-13sec and total floating time (TFT) more than 12hr. Moreover, the % buoyancy was found to be 97.62± 4.78%. LAFU-SF-Microspheres showed in-vitro % drug release up to 92.41±4.29% adopting the first-order model. The FTIR indicated successful incorporation of LAFU in LAFU-SF-Microspheres. The DSC and PXRD indicated the disrupted crystallinity of LAFU in LAFU-SF-Microspheres. The SEM images of microspheres displayed spherical shapes with smooth textures. Conclusion: SF microspheres can be fruitfully applied for customized floating and release patterns of drugs with distinct solubility classes. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_917650 _aNangare, Sopan |
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| 773 | 0 |
_x0019-5464 _dBengluru Association of Pharmaceutical Teachers of India (APTI) _tIndian journal of pharmaceutical education and research |
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| 856 |
_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-396.pdf _yClick here |
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| 942 |
_2ddc _cAR |
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