000			a
999			_c17366 _d17366
003			OSt
005			20220830095408.0
008			220830b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_917668 _aMadathil, Sri Rashmy
245			_aEvaluation of anticancer potential of mimosa diplotricha ethanolic leaf extract on N-methyl-N- nitroso urea induced colorectal carcinogenesis in wistar albino rats
250			_aVol.56(2), Apr-June
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022
300			_a479-488p.
520			_aBackground: Colorectal Cancer, (CRC) ranks third among global cancer incidence statistics and occupies fourth position as far as cancer related death is concerned and the aim of the study is to evaluate the therapeutic potential of Mimosa diplotricha ethanolic leaf extract in chemically induced colorectal carcinogenesis in Wistar albino rats. Materials and Methods: CRC was induced by intrarectal instillation of N-Methyl-N-Nitrosourea (MNU), 2mg per rat in 0.5ml of distilled water three times a week for five weeks. Rats were grouped as control, induced, induced and standard drug treated (15mg/kg.bw), induced and plant extract treated (in two doses 200mg/kg.bw and 400mg/kg.bw) and normal rats with respective plant extract treatment (200mg/kg.bw and 400mg/kg.bw). Treatment were carried out for 60 days followed which animals were euthanized and serum markers, oxidative stress, microbial enzymatic, histological and immunohistochemical parameters were analysed. Results: M. diplotricha was found to be effective in the down regulation of serum inflammatory and tumour markers like tumour necrosis factor alpha, transforming growth factor beta, carcinoembryogenic antigen and colon cancer specific antigen-4 levels. Oxidative stress parameters and histological data also supported the therapeutic efficacy of M. diplotricha. Expression of anti-apoptotic protein Bcl-2 was also found be downregulated in induced animals treated with M. diplotricha as evident from immunohistochemical data. Conclusion: The results of present research suggest that M. diplotricha ethanolic leaf extract showed a significant therapeutic potential against chemically induced colorectal carcinogenesis.
650		0	_94639 _aPHARMACEUTICS
700			_917669 _aKannappan, Poornima
773	0		_tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-479.pdf _yClick here
942			_2ddc _cAR