000			a
999			_c17377 _d17377
003			OSt
005			20220901104901.0
008			220901b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_917685 _a Zhang, Yi-Heng
245			_aSynthesis of transition metal complexes of isoniazid derivatives and urease inhibition activity detection
250			_aVol.56(2), Apr-June
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022
300			_a573-579p.
520			_aIt have been reported that the transition metal complex of Schiff base ligands have the ability to inhibit urease. Herein, in this manuscript, two novel transition metal complexes [Cd2 (L)2·(H 2 O)] (1), [Pb(L)·, [Pbe2 ) were synthesized based on chelating hydrazone ligand N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds were tested by single crystal X-ray diffraction and determined by structure and tested for urease resistance in vitro. The complex 2 exhibited better the activities of inhibiting than the positive control acetohydroxamic acid with an IC50 =2.5 μM, while the complex 1 showed weak activity, and complex 2 acted as an effective urease inhibitor.
650		0	_94639 _aPHARMACEUTICS
700			_917686 _aFang, Ze-Yu
773	0		_tIndian journal of pharmaceutical education and research _x0019-5464 _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-573.pdf _yClick here
942			_2ddc _cAR