000			a
999			_c17595 _d17595
003			OSt
005			20220922113657.0
008			220922b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_918027 _aSelliamman, Ravi Mahi Priya
245			_aFormulation of mupirocin adsorbed silver nanoparticle with antibiofilm agents for enhancing antibacterial activit
250			_aVol.56(1), Jan-Mar
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022
300			_a50-57p.
520			_aIntroduction: Biofilm is a complex structure of microbiome having different bacterial colonies or single type of cells in a group, adhere to the surface to produce infections. Nanoparticles (NPs) are widely used in different technological fields especially medicine because of their antibacterial properties. Silver nanoparticles (AgNPs) possess antimicrobial and antibiofilm property against various microbial infections. Objectives: The main objective of this study was to develop new formulations and characterization of mupirocin loaded silver nanoparticles with various anti biofilm agents. Methods: Silver nanoparticles formulations were prepared by tannic acid (TA) with trisodium citrate (TSC), Para-amino salicylic acid (PASA) and ascorbic acid (ASC) as both reducing and antibiofilm agents against Staphylococcus aureus followed by surface adsorption of Mupirocin (MUP). Transmission Electron Microscope (TEM) shows that the nanoparticles are roughly spherical in shape which was also confirmed by Atomic Force Microscopy (AFM). The particle size was in the range between 50 nm – 250 nm and found to be statistically significant ( p<0.001) between the three AgNP formulations. In vitro drug release using the dialysis membrane showed a maximum release of 90% ± 2.343 in AgNPs (TSC TA) formulation at the end of 7 hr with the maximum drug entrapment of 93.75%. The formulations were tested for antimicrobial activity against S. aureus. The results were statistically compared using one way ANOVA and student t test. Conclusion: There is no significant difference in antibacterial activity between three AgNP formulations. However the best synergistic activity against planktonic S. aureus bacteria was shown by AgNP-PASA inspite of its minimal drug release when compared to AgNPs (TSC TA).
650		0	_94639 _aPHARMACEUTICS
700			_918028 _aRoselin, Rajandurai Baby
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-50.pdf _yClick here
942			_2ddc _cAR