000			a
999			_c17596 _d17596
003			OSt
005			20220922114446.0
008			220922b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_918029 _aGohil, Dipti
245			_aEffect of formulation variables on fabrication of risperidone loaded nanoparticles for sustained drug delivery
250			_aVol.56(1), Jan-Mar
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022
300			_a58-64p.
520			_aAim/ Background: Risperidone, an atypical antipsychotic agent, is used in the treatment of psychotic disorders due to its lower Extra Pyramidal side Effects (EPS) than conventional antipsychotics. Materials and Methods: The objective of the present investigation is to study the effect of formulation variables using 32 factorial design; on preparation of nanoparticles to provide sustained drug release for a prolonged period of time; enhancing therapeutic efficacy by reducing dose dependent side effects. Study include formulation of nanoparticles by the nanoprecipitation method and optimization of the formulation parameters such as Amount of Polymer and Surfactant concentration as independent variables and Particle size and % entrapment efficiency as dependent variables using design of experiment; a statistical tool. Results: Optimized formulation of nanoparticles was characterized for various physicochemical parameters. The particle size was found to be 213.3 nm with 82.89% drug entrapment. Conclusion: In vitro drug release study and Pharmacodynamic study portend promising results of drug delivery for longer duration. Key words: Schizophrenia, Risperidone, Nanoparticles, 32 factorial design, Catalepsy.
650		0	_94639 _aPHARMACEUTICS
700			_918030 _aShah, Nirmal
773	0		_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-58.pdf _yClick here
942			_2ddc _cAR