000			a
999			_c17624 _d17624
003			OSt
005			20220923115316.0
008			220923b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_918072 _a Islam, Mohammed Monirul
245			_aHydroxychloroquine metabolites – an exploratory computational study
250			_aVol.56(1), Jan-Mar
260			_aKarnataka _bAssociation of Pharmaceutical Teachers of India (APTI) _c2022
300			_a215-223p.
520			_aBackground: HCQ has been found to provide the immunomodulation that helps to abate the possible cytokine storm response caused by the SARS COVID-19 virus and subsequent failures of major organs. It is also being used historically in treating Malaria and Rheumatoid arthritis and is known to be useful in cancer treatment. However, it shows a half-life of up to 70 days and has severe adverse effects including gastric disorders and retinopathy. Hypothesis: Therefore, we propose to explore some of its metabolites/ intermediates namely Desethyl hydroxychloroquine (DHCQ), Desethyl chloroquine (DCQ), and Bis-desethyl chloroquine (BDCQ) as alternate drug systems with minimized toxicity. Results and Discussion: The structural and spectral studies of these lead compounds to be unraveled using computational modeling and the evaluation of ADME parameters such as absorption, distribution, metabolism, and excretion would be performed using the SwissADME tool to assess the drug-likeness and medicinal chemistry friendliness. The future scope of the work involves the docking studies of these compounds to assess the therapeutic compliance for the treatment of viral infections and rheumatoid arthritis.
650		0	_94639 _aPHARMACEUTICS
700			_918073 _aSingh, Purna Sivarama
773	0		_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes-56-1-215.pdf _yClick here
942			_2ddc _cAR