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_aAIKTC-KRRC _cAIKTC-KRRC |
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_923267 _aChandan, Lakkaraju |
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| 245 | _aFree radical scavenging activity of pleurotus ostreatus against ccl4-induced hepatic damage in wister rats | ||
| 250 | _aVol.15(12), Dec | ||
| 260 |
_aBhopal _bInnovare Academic Sciences Pvt Ltd _c2023 |
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| 300 | _a17-22p. | ||
| 520 | _aObjective: The present study was aimed to evaluate the anti-oxidant effect of Pleurotus ostreatus using in vitro and in vivo methodology. Methods: Methanolic extract of Pleurotus ostreatus (MEPO) was prepared by cold maceration technique. Rats weighing 150-200 g were divided into 6 groups of six each (n=6). Group I served as control (0.9% Nacl), group II was considered as the positive control, administered with CCl4 dissolved in olive oil (intraperitoneal injection at 0.5 mg/kg body weight), group III was given with CCl4+standard drug sylimarin (100 mg/kg body weight, p. o.), group IV, V and VI were administered with CCl4+MEPO at 200, 400 and 800 mg/kg orally for a period of 21 d. The liver injury was induced by the administration of CCl4 intraperitoneally with a single dose of CCl4 (0.5 mg/kg body weight) as a 1:1 (v/v) solution in olive oil. Results: In the Hydroxyl free radical scavenging assay, the IC50 values of the test extract was found to be 72.1±1.68 as compared with the standard drug (IC50-66.3±1.02), which was considered as significant (***p<0.001). In the reducing power assay, all the absorbance values were comparable to standard ascorbic acid and showed maximum reducing ability at the concentration of 500 µg/ml. In the in vivo anti-oxidant study, administration of MEPO to injury-induced rats at the dose of 400 and 800 mg/kg, significantly increased (**p<0.001) the levels of SOD and CAT, with a significant reduction in the MDA levels. Conclusion: The current study explored a potential source for anti-oxidants in the methanolic extract of Pleurotus ostreatus, thus seems to be protective to liver in CCl4-induced hepatic injury. | ||
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_94639 _aPHARMACEUTICS |
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_923268 _aBhikshapathi, Darna |
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| 773 | 0 |
_tInternational journal of pharmacy and pharmaceutical science _dBhopal Innovare Academic Sciences Pvt Ltd _x2656-0097 |
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| 856 |
_uhttps://journals.innovareacademics.in/index.php/ijpps/article/view/49478 _yClick here |
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_2ddc _cAR |
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