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| 005 | 20250304113531.0 | ||
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| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_925499 _aPriyanka, Sonwane |
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| 245 |
_aFormulation of pregabalin-loaded trimethyl chitosan microspheres for nasal drug delivery _b: in vitro, ex vivo and in vivo characterization |
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| 250 | _aVol.58(4), Oct-Dec | ||
| 260 |
_aBanagalore _bAssociation of Pharmaceutical Teachers of India (APTI) _c2024 |
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| 300 | _a1215-1224p. | ||
| 520 | _aPolar drugs make it difficult to cross nasal cells. Trimethyl Chitosan (TMC) microspheres help absorption by opening junctions, increasing drug retention. Pregabalin absorbs well orally but delays crossing the brain, limiting emergency seizure treatment. The present study aimed to develop pregabalin-loaded TMC microspheres for intranasal administration in epilepsy. Materials and Methods: The microspheres were prepared by ionotropic gelation method using TMC and glutaraldehyde by varying the formulation and processing parameters and have been characterized for the physicochemical, drug release and pharmacodynamic properties. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_925500 _aQutub, Mohammad |
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| 773 | 0 |
_tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 |
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| 856 |
_uhttps://ijper.org/article/doi/6046/ _yClick here |
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| 942 |
_2ddc _cAR |
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