000			a
999			_c23004 _d23004
003			OSt
005			20250620110302.0
008			250620b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_926512 _aAhsan, Marya
245			_aMetformin-induced eyelid myokymia
250			_aVol.56(5), Sep-Oct
260			_aNew Delhi _bWolter Kluwer _c2024
300			_a358-360p.
520			_aMetformin, an insulin-sensitizer, is used in the treatment of polycystic ovarian syndrome (PCOS) in obese women as it helps in weight loss and regularizes the menstrual cycle. However, impaired absorption of Vitamin B12 due to metformin has also been hypothesized. Here, we report the case of a 39-year-old woman prescribed metformin for PCOS, presenting with an unusual symptom of eyelid myokymia. She developed distressing unilateral eyelid twitching, not responsive to conservative management or oral methylcobalamin. She was a nonsmoker, nonalcoholic, and nor caffeine-abuser. Other confounding factors such as stress, sleep deprivation, or eye strain were not evident. The only significant finding was borderline low Vitamin B12 levels. The symptoms subsided on discontinuation of metformin and reappeared when metformin was reintroduced. Although eyelid myokymia is a self-limiting benign condition, it can also be triggered by drugs and affect the quality of life. Practitioners should monitor Vitamin B12 levels during metformin therapy to prevent adverse effects.
650		0	_94774 _aPHARMACOLOGY
700			_926513 _aNizami, Deba Jalal
773	0		_dAndheri - Mumbai Wolters Kluwer India Private Limited _x0253-7613 _tIndian Journal of Pharmacology
856			_uhttps://journals.lww.com/iphr/fulltext/2024/09000/metformin_induced_eyelid_myokymia.9.aspx _yClick here
942			_2ddc _cAR