000			a
999			_c23225 _d23225
003			OSt
005			20250804104833.0
008			250804b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_926925 _aBandil, Varsha
245			_aFormulation, optimization and characterization of plga-chitosan nanoparticles containing vinorelbine ditartrate
250			_aVol.58(1), Jan-Mar
260			_aBanaglore _bAssociation of Pharmaceutical Teachers of India (APTI) _c2024
300			_a99-108p.
520			_aBackground: The prime objective of our investigation was to optimize PLGA-chitosan nanoparticles containing vinorelbine ditartrate. Materials and Methods: The Vinorelbine ditartrate nanoparticles were formulated using emulsion method followed by probe sonication to reduce the size. A three factor three level Box-Behnken Design has been implemented to optimize chitosan, Poloxamer 188 and sonication time (independent variables) for particle size, polydispersity index and entrapment efficiency (%) as the measured responses. Particle size, zeta potential, surface morphology, entrapment effectiveness, and in vitro drug release were all evaluated for the optimised formulation. Results: The optimized PLGA-chitosan nanoparticle exhibited particles size of 161.22 nm with polydispersity index of 0.229 and zeta potential value of 10.99 mV. The formulation exhibited 78.9% entrapment of vinorelbine ditartrate. The nanoparticle was able to sustain the release of vinorelbine for more than 140 hr in the in vitro release studies. Conclusion: From studying the obtained results, it could be concluded from the investigation that PLGA-chitosan nanoparticles could be good approach to improve the bioavailability of the entrapped drug.
650		0	_94639 _aPHARMACEUTICS
700			_926908 _aGupta, Jeetendra Kumar
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://archives.ijper.org/article/2159 _yClick here
942			_2ddc _cAR