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040 _aAIKTC-KRRC
_cAIKTC-KRRC
100 _aSoni, Hitesh M.
_927648
245 _aEffects of combination of aliskiren and pentoxyfylline on renal function in the rat remnant kidney model of chronic renal failure
250 _aVol.47(1), Jan-Feb
260 _aMumbai
_bWolter Kluwer
_c2015
300 _a80-85p.
520 _aThe aim was to investigate the nephroprotective effect of combination of aliskiren (ASK), a direct renin inhibitor and pentoxifylline (PTX), inhibitor of tumor necrotic factor-alpha (TNF-alpha), in rat remnant kidney model of chronic kidney disease (CKD). Materials and Methods: Nephrectomized (NPX) rats were treated with ASK (10 mg/kg, p.o.), PTX (100 mg/kg, p.o.), and combination of PTX + ASK once daily for 28 days. We have performed analysis of various renal injury parameters after 4 weeks of treatment. Results: Treatment with PTX, ASK and combination showed significant improvement in urea, creatinine and total protein in plasma when compared with vehicle treated group in NPX rats. ASK and combination of PTX + ASK elicited significant reduction in blood pressure but PTX alone did not produce blood pressure reduction. ASK treatment showed significant elevation in TNF-alpha, whereas PTX and ASK + PTX showed significant reduction in TNF-alpha in plasma. Histopathologically, the extent of the kidney injury was similar in NPX + vehicle and NPX + ASK-treated rats. PTX and ASK + PTX-treated group showed lesser extent of kidney injury. There was good correlation of mRNA expression levels of kidney injury molecule-1 and bradykinin B1 receptor data with histopathological findings in kidney samples and elevated TNF-alpha levels in plasma.
650 0 _aPHARMACOLOGY
_94774
700 _aPatel, Praful P.
_927649
773 0 _dAndheri - Mumbai Wolters Kluwer India Private Limited
_tIndian Journal of Pharmacology
_x0253-7613
856 _uhttps://journals.lww.com/iphr/fulltext/2015/47010/effects_of_combination_of_aliskiren_and.15.aspx
_yClick here
942 _2ddc
_cAR
999 _c23700
_d23700