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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_aPatel, Sonam _927679
245			_aEffect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice
250			_aVol.47(2), Mar-Apr
260			_aMumbai _bWolter Kluwer _c2015
300			_a173-176p.
520			_aThere is a strong association between depression and anxiety. Duloxetine, an antidepressant agent, is also used in the treatment of anxiety. Hydroxyzine is preferred over benzodiazepines in the treatment of anxiety. Present study was designed to study the impact of a combination of duloxetine with hydroxyzine in treatment of anxiety. Materials and Methods: Mice received intraperitoneal injection of normal saline (10 ml/kg), duloxetine alone (10 mg/kg), hydroxyzine alone (10 mg/kg), and hydroxyzine plus duloxetine (5 mg/kg, each). Results: The in vivo results (elevated plus maze and light/dark transition tests) showed significant anxiolytic activity with the hydroxyzine treatment than the control group. The brain monoamines were significantly increased in hippocampi, cerebral cortices, and whole brain in drug-treated groups than in the control group. The group receiving the combination showed similar results in the in vivo models and in vitro tests (brain monoamine estimations) than respective monotherapies, with the exception of a greater increase of norepinephrine levels in cerebral cortices in duloxetine-treated group.
650		0	_aPHARMACOLOGY _94774
700			_aKale, Pravin Popatrao _916741
773	0		_tIndian Journal of Pharmacology _dAndheri - Mumbai Wolters Kluwer India Private Limited _x0253-7613
856			_uhttps://journals.lww.com/iphr/fulltext/2015/47020/effect_of_a_combination_of_duloxetine_with.8.aspx _yClick here
942			_2ddc _cAR
999			_c23728 _d23728