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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_aMerter, Ayse Arducoglu _927684
245			_aProtective effects of amifostine on ischemia-reperfusion injury of rat kidneys
250			_aVol.47(2), Mar-Apr
260			_aMumbai _bWolter Kluwer _c2015
300			_a185-189p.
520			_aAmifostine is a drug which can eliminate free oxygen radicals that appear in the body after radiation or chemotherapeutic agent exposure. It is used to decrease the renal toxicity of cisplatin. The aim of this study was to determine the role of amifostine in warm ischemia kidney model for prevention of ischemia/reperfusion injury and also to find out the mechanism for prevention from ischemia/reperfusion injury if such an effect does exist. Materials and Methods: Adult female rats (n = 40) that used in our study were divided into three groups. Group 1: Control (n = 8), group 2: Ischemia-control (n = 16), group 3: Amifostine treated (n = 16). The effect of amifostine on ischemia/reperfusion injury investigated in rat kidneys. Results: At the 7th day, blood urea nitrogen level was statistically significantly higher in ischemia-control group than all groups (P = 0.001) and mean serum creatinine levels were found to be the highest in ischemia-control group (P = 0.091). Mean malondialdehyde levels in left kidneys removed on the 7th day were not significantly different (P = 0.105) at all three groups. Between ischemia-control group and amifostine group, there was a significant difference in reduced glutathione (GSH) levels (P = 0.001). In amifostine group, grade 4 necrosis was not detected neither on 7th day nor day 0.
650		0	_aPHARMACOLOGY _94774
700			_aMayir, Burhan _927685
773	0		_dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology _x0253-7613
856			_uhttps://journals.lww.com/iphr/fulltext/2015/47020/protective_effects_of_amifostine_on.11.aspx _yClick here
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