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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_aKale, Pravin Popatrao _916741
245			_aEnhancement of nootropic effect of duloxetine and bupropion by caffeine in mice
250			_aVol.47(2), Mar-Apr
260			_aMumbai _bWolter Kluwer _c2015
300			_a199-201p.
520			_aThe existing evidence suggests an association between depression and memory impairment. The objective of present study was to assess the effect of low dose caffeine with duloxetine and bupropion on memory. Materials and Methods: Mice were divided randomly into seven groups. Intra-peritoneal treatment of normal saline (10 ml/kg), caffeine (10 mg/kg), duloxetine (10 mg/kg), bupropion alone (10 mg/kg), caffeine + duloxetine (5 mg/kg, each), caffeine + bupropion (5 mg/kg, each), and bupropion + duloxetine (5 mg/kg, each) were given to groups I-VII, respectively. Elevated plus maze was used to evaluate transfer latency (TL) and Morris water maze was used to estimate the time spent in target quadrant. Results: Caffeine with duloxetine treated group was better than other combination treated groups in terms of a significant decrease in TL and increase in the time spent in target quadrant recorded. Conclusion: Combining lower dose of caffeine with duloxetine may enhance cognitive benefits than respective monotherapies.
650		0	_aPHARMACOLOGY _94774
700			_aAddepalli, Veeranjaneyulu _927690
773	0		_tIndian Journal of Pharmacology _x0253-7613 _dAndheri - Mumbai Wolters Kluwer India Private Limited
856			_uhttps://journals.lww.com/iphr/fulltext/2015/47020/enhancement_of_nootropic_effect_of_duloxetine_and.14.aspx _yClick here
942			_2ddc _cAR
999			_c23736 _d23736