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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_aLee, Jun Yeol _927718
245			_aSingle intramuscular injection of diclofenac sodium in febrile pediatric patients
250			_aVol.47(3), May-Jun
260			_aMumbai _bWolter Kluwer _c2015
300			_a275-279p.
520			_aThere are few reports on the effectiveness and safety of intramuscular (IM) antipyretic injections in pediatric patients. This study reports the efficacy and adverse effects of a single IM injection of diclofenac sodium in pediatric patients. Materials and Methods: This was an observational study in which records of febrile pediatric patients presenting to the emergency department were analyzed. Subjects included pediatric patients presenting to the emergency department with a temperature of 38°C or higher. Infants under 12 months of age were excluded. Patients were excluded if they received antipyretics within 4 h prior to presenting to the emergency department. Body temperature was measured at 30–60 min intervals following diclofenac sodium injections. Fever alleviation was defined as the temperature decline to 1°C below the temperature at presentation. Patients who received diclofenac sodium twice or more on different days were observed for side effects such as allergic reaction. Records from the emergency department and outpatient clinics were analyzed. Results: The dose of diclofenac sodium injected was approximately 2 mg/kg. The average time elapsed until antipyresis was 69.1 ± 23.8 min. The average temperature reduction after 1 h was 1.1 ± 0.6°C. The average proportion of temperature change after 1 h was 40.6 ± 22.2%. During the period at the emergency department, there were no reported serious side effects.
650		0	_aPHARMACOLOGY _94774
700			_a Cho, Jun Hwi _927719
773	0		_dAndheri - Mumbai Wolters Kluwer India Private Limited _x0253-7613 _tIndian Journal of Pharmacology
856			_uhttps://journals.lww.com/iphr/fulltext/2015/47030/single_intramuscular_injection_of_diclofenac.7.aspx _yClick here
942			_2ddc _cAR
999			_c23758 _d23758