000			01967 a2200217 4500
003			OSt
005			20251210094955.0
008			251210b |||||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_aSharma, Hitender _927726
245			_aNeuropharmacological activities of Taxus wallichiana bark in Swiss albino mice
250			_aVol.47(3), May-Jun
260			_aMumbai _bWolter Kluwer _c2015
300			_a299-303p.
520			_aThe bark of Taxus wallichiana is widely used for preparing a decoction and consumed as a tea by several tribal communities of the Indian subcontinent. The sedative, motor coordination, anxiolytic, and antidepressant effects of the hydroalcoholic extract of T. wallichiana bark and its ethylacetate fraction were evaluated in mice models of behavior analysis. Materials and Methods: The effects were evaluated on diazepam-induced sleeping time, elevated plus maze and light and dark box, and on the forced swimming test. General locomotor activity and motor coordination effects were evaluated in the actophotmeter and rota-rod tests respectively. Statistical Analysis: Results are expressed as mean ± standard error of the mean. Statistical analysis was performed using ANOVA, followed by post-hoc Dunnett's test. *P < 0.05, **P < 0.01, ***P < 0.001 were considered as significant. Results: Both the hydroalcoholic extract and ethylacetate fraction showed a marked decrease in latency of sleep onset, prolonged the diazepam-induced sleeping time, decreased spontaneous locomotor activity; whereas ethylacetate fraction produced anxiolytic and antidepressant activity.
650		0	_aPHARMACOLOGY _94774
700			_aGarg, Munish _927727
773	0		_dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology _x0253-7613
856			_uhttps://journals.lww.com/iphr/fulltext/2015/47030/neuropharmacological_activities_of_taxus.11.aspx _yClick here
942			_2ddc _cAR
999			_c23763 _d23763