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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_aSong, In-Kyung _927743
245			_aEstimation of the plasma effect site equilibration rate constant of sufentanil in children using the time to peak effect of heart rate and blood pressure
250			_aVol.47(4), Jul-Aug
260			_aMumbai _bWolter Kluwer _c2015
300			_a360-364p.
520			_aAlthough targeting the effect site concentration may offer advantages over the traditional forms of administering intravenous anesthetics, it is not applicable for sufentanil in children because its plasma effect site equilibration rate constant (ke0) is not known yet. We estimated ke0 of sufentanil in children using the time to peak effect (tpeak) method. Materials and Methods: Under general anesthesia, sufentanil tpeak was measured after administration of a submaximal bolus dose by means of the decrease in heart rate, blood pressure and calculated approximate entropy (ApEn) of electroencephalogram in 105 children (age range: 3–11 years). ke0 was estimated using tpeak and known sufentanil pharmacokinetic parameters in normal children. Results: The mean tpeaks were measured as 44 ± 22 s and 227 ± 91 s by heart rate and by mean blood pressure respectively. The estimated ke0 were 5.16/min and 0.49/min by heart rate and blood pressure respectively. tpeak could not be measured using the ApEn, thus ke0 could not be calculated by ApEn in children.
650		0	_aPHARMACOLOGY _94774
700			_aLee, Ji-Hyun _927744
773	0		_dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology _x0253-7613
856			_uhttps://journals.lww.com/iphr/fulltext/2015/47040/estimation_of_the_plasma_effect_site_equilibration.4.aspx _yClick here
942			_2ddc _cAR
999			_c23776 _d23776