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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_aSuresh Kumar _910050
245			_aDual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin
250			_aVol.47(4), Jul-Aug
260			_aMumbai _bWolter Kluwer _c2015
300			_a444-446p.
520			_aThe brain of mammals contains two major form of cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The dual inhibition of these enzymes is considered as a promising strategy for the treatment of neurological disorder such as Alzheimer's disease (AD), senile dementia, ataxia, and myasthenia gravis. The present study was undertaken to explore the anticholinesterase inhibition property of allicin. Materials and Methods: An assessment of cholinesterase inhibition was carried out by Ellman's assay. Results: The present study demonstrates allicin, a major ingredient of crushed garlic (Allium sativum L.) inhibited both AChE and BuChE enzymes in a concentration-dependent manner. For allicin, the IC50 concentration was 0.01 mg/mL (61.62 μM) for AChE and 0.05 ± 0.018 mg/mL (308.12 μM) for BuChE enzymes.
650		0	_aPHARMACOLOGY _94774
773	0		_dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology _x0253-7613
856			_uhttps://journals.lww.com/iphr/fulltext/2015/47040/dual_inhibition_of_acetylcholinesterase_and.20.aspx _yClick here
942			_2ddc _cAR
999			_c23793 _d23793