000			00722nam a2200205Ia 4500
999			_c2497 _d2497
005			20190503111017.0
008			180803s9999 xx 000 0 und d
020			_a978-3-906390-53-5
040			_aAIKTC-KRRC _cAIKTC-KRRC
041			_aENG
082			_a612.015 _bTES _2DDC23
100			_aTennant, Rachel _9136
245		0	_aBiochemistry of drug metabolism
246			_aPrinciples, readox reaction hydrolysis
250			_a2nd
260			_aNA _c2008
300			_a319, 24.1*171 Pages _bPaperback
520			_aThe first of the two volumes is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug metabolism in animals and humans. This is followed by an introduction to the all-important issue of the consequences of drug and xenobiotic metabolism, providing an initial overview of pharmacokinetic, pharmacological and toxicological consequences. The last chapter examines drug metabolism in the context of drug research, with a focus on medicinal chemistry. The second part is a major component of the book, corresponding to the role of oxidoreductases as major agents of metabolism. Cytochromes P450 receive particular attention, namely their multiplicity, structure, catalytic mechanisms, and the various reactions they catalyze, while other oxidoreductases are also presented, such as flavin monooxygenases, monoamine oxidases and other amine oxidases, aldehyde oxidase and xanthine dehydrogenase, peroxidases, and dehydrogenases-reductases. Each drug-metabolizing enzyme or enzyme family begins with an Enzyme Identity Card summarizing its nomenclature and biochemical essentials. Part Three begins with a survey of the classification, properties and catalytic mechanism of the innumerable hydrolases known or suspected to play a role in xenobiotic metabolism. The focus then shifts to a systematic presentation of the various substrate classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties. With a foreword by Prof Leslie Z. Benet, the world's best and best-known biopharmaceutical scientist
650		0	_94762 _aBIOCHEMISTRY
700			_aKramer, Stefanie D. _91254
856			_uhttps://ndl.iitkgp.ac.in/result?q={%22t%22:%22search%22,%22k%22:%22PHARMACEUTICAL%20BIOCHEMISTRY%22,%22s%22:[%22DDC=\%22600%3A%3ATechnology\%22%22],%22b%22:{%22filters%22:[]}}
942			_cBK _2ddc