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005			20190514115929.0
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040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_97674 _aDas, Kusal K.
245			_aSubchronic hypoxia pretreatment on brain pathophysiology in unilateral common carotid artery occluded albino rats
250			_aVol. 50(4), July-August
260			_aMumabai _c2018 _bWolter Kluwer
300			_a185-191
520			_aThis study was aimed to assess the effect of unilateral common carotid artery occlusion on brain pathophysiology in rats pretreated with subchronic hypoxia. MATERIALS AND METHODS: Rats (200 ± 20 g) were randomized into three groups: Group 1 served as sham, Group 2 were normoxic (21% O2 and 79% N2), and Group 3 were hypoxia preconditioned (10% O2 and 90% N2) for 21 days before left common carotid artery occlusion (LCCAO). The LCCAO was done for 75 min followed by reperfusion for 12 h. Neurological scores were recorded. Serum malondialdehyde (MDA) and nitric oxide (NO) levels at pre- and 12 h post-LCCAO were measured. Brain histopathological assessments were also done. RESULTS: Higher neurological deficits scores in Group 2 as compared to Group 3 rats were noticed. Serum MDA and NO levels at 12 h post-LCCAO in Group 2 rats showed significant elevation as compared to preocclusion levels. Group 3 rats did not show such elevations. On histopathology of left and right cerebral hemispheres of Group 1 (sham) did not show any specific changes. In Group 2 rats, the right cerebral hemisphere (nonoccluded) showed no areas of ischemia-induced brain changes, but in the left side (occlusive), there were features of ischemic brain damage including cerebral edema. In the case of Group 3 rats, there were less ischemic damages in the left occluded side as compared to the left side of the Group 2 rats. CONCLUSION: This study clearly demonstrates that subchronic hypoxia pretreatment can reduce ischemic brain injury by unilateral common carotid artery occlusion in rats.
650		0	_94774 _aPHARMACOLOGY
700			_97675 _aYandigeri, Saeed M.
700			_97676 _aPatil, Bheemshetty S.
773	0		_x0253-7613 _dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology
856			_yClick here _uhttp://www.ijp-online.com/article.asp?issn=0253-7613;year=2018;volume=50;issue=4;spage=185;epage=191;aulast=Das;type=0
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