000			a
999			_c8349 _d8349
003			OSt
005			20190514115929.0
008			190226b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_97677 _aTripathy, Ratikanta
245			_aCutaneous adverse drug reactions with fixed-dose combinations: Special reference to self-medication and preventability
250			_aVol. 50(4), July-August
260			_aMumbai _c2018 _bWolter Kluwer
300			_a192-196
520			_a To identify the association of cutaneous adverse drug reactions (CADRs) with use of fixed-dose combinations (FDCs) and to compare the occurrence of preventable CADRs between self-medication and prescribed medication of FDCs. PATIENTS AND METHODS: All cases of suspected CADRs with the use of FDCs were collected, and causality assessment was carried out using the WHO UMC scale. The burden of CADRs on self-medication and prescribed medication was found out. Preventability status was analyzed by Schumock and Thornton Criteria and compared between self-medication and prescribed medication. RESULTS: A total of 74 CADRs were detected; 68.91% were detected with antimicrobial and 31.09% with nonsteroidal anti-inflammatory drug-based FDCs. Fluoroquinolones + nitroimidazole was the most commonly suspected medications. Majority of CADRs (44.59%) were fixed-drug eruptions, which was significantly higher than others (P = 0.002). Analysis of preventability showed that there was a significantly higher occurrence of definitely preventable CADRs in self-medication group (40%) in comparison to prescribed group (6.81%), P = 0.028. CONCLUSIONS: Self-medication with FDCs is quite common and associated with a higher rate of preventable CADRs in comparison to that in prescribed medication.
650		0	_94774 _aPHARMACOLOGY
700			_97678 _aPattnaik, Kali Prasad
700			_97679 _aDehury, Suhasini
773	0		_dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology _x0253-7613
856			_yClick here _uhttp://www.ijp-online.com/article.asp?issn=0253-7613;year=2018;volume=50;issue=4;spage=192;epage=196;aulast=Tripathy;type=0
942			_2ddc _cAR