| 000 | a | ||
|---|---|---|---|
| 999 |
_c8451 _d8451 |
||
| 003 | OSt | ||
| 005 | 20190315092633.0 | ||
| 008 | 190307b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
||
| 100 |
_97885 _aHidayati, Sholihatil |
||
| 245 | _aRegulation of ethyl acetate fraction from moringa olefera leaves to improve lipid metabolism and insulin sensitivity in type 2 diabetes | ||
| 250 | _aVol. 10(10), July-August | ||
| 260 |
_aM. P. _bInnovare Academic Sciences Pvt Ltd _c2018 |
||
| 300 | _a78-82 | ||
| 520 | _aObjective: Moringa oleifera is a medicinal plant species that has potential as an antidiabetic. The present study was designed to evaluated molecullar mechanism antidi abetic ethyl acetate fraction of Moringa oleiferaleaves (EAFML). Methods: The study was conducted on 30 male wistar rats which were induced with the combination of streptozotocin and nicotinamide by intraperitoneal administration to make a model of type 2 diabetes. After the diabetic induction, all rats were divided into six group and once daily administered orally EAFML in doses standardized quercetine. The treatment was given for ten days, and on the final treatment, all rats were checked their blood glucose level and lipid profile. The skeletal muscles and liver were taken to examine glucose transporter-4 (GLUT4) expression by immunohistochemistry. Results: The result of this study shows that the blood glucose level in diabetic rats with the treatment of EAFML decreased significantly from 355.8±83.7 mg/dL to 177.5±89.3 mg/dL. The cholesterol decreased significantly from 105.2±47.4 mg/dL to 58.6±6.9 mg/dL and low-densitylipoprotein (LDL) in diabetic rats with the treatment of EAFML decreased significantly compared to control group from 175.6±41.9 mg/dL to 95.3±8.0 mg/dL. The expression of GLUT4 in skeletal muscles increased from 0.7±1.0 to 3.9±1.1 and in the liver increased significantly from 1.8±1.3 to 2.9±1.9. Conclusion: The EAFML can decrease blood glucose level, cholesterol and low-density lipoprotein in type 2 diabetic rat model. Other than that, this fraction can improve insulin sensitivity by the increase of GLUT4 expressions. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
|
| 700 |
_97886 _aSulistyawati, Rini |
||
| 700 |
_97887 _aNurani, Laela Hayu |
||
| 773 | 0 |
_tInternational journal of pharmacy and pharmaceutical science _x0975 – 1491 _dBhopal Innovare Academic Sciences Pvt Ltd |
|
| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/27845/15892 _yClick here |
||
| 942 |
_2ddc _cAR |
||