000			a
999			_c8620 _d8620
003			OSt
005			20190514115933.0
008			190324b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_98215 _a Saini, Vikas
245			_aProspective randomized study to evaluate safety and efficacy of heparin topical solution (1000 IU/ml) compared to heparin topical gel (200 IU/g) in prevention of infusion‑associated phlebitis
250			_aVol. 50(6), November-December
260			_aMumbai _bWolter Kluwer _c2018
300			_a344-349p.
520			_aOBJECTIVES: Thrombosis and thrombophlebitis of the superficial venous system are common in hospitalized patients. Efficacy and safety of topical quick penetrating solution (QPS) of heparin were compared to heparin sodium topical gel for the prevention of infusion‑associated phlebitis.MATERIALS AND METHODS: Patients aged 18–65 years undergoing intravenous cannulation for at least 72 h were enrolled and randomized to receive 6–8 drops of topical solution of heparin (Group sodium topical solution [QPS]) or1 g of topical gel (Group GEL) over the cannulated vein every 8 hourly for a total of 10 doses. Enrolled patients were monitored every 8 ± 1 h for phlebitis using visual infusion phlebitis scale. The primary aim was to compare the proportion of patients with Grade 0, I, and II phlebitis at the end of 72 h of treatment period.RESULTS: Number of patients assessed for eligibility was 110; 26 excluded and 84 randomized. Analysis was done for 41 administered heparin QPS and 33 administered heparin gel as the rest were lost to follow‑up. No phlebitis was reported in 32% of patients in QPS group and 9% in GEL group (P =0.0019). Proportion of patients with Grade I and Grade II phlebitis was 22.9% and 13.5% with QPS and 35.13% and 22.97% with gel, respectively, and the difference was statistically significant. Mean time to develop Grade I (Group QPS = 59.7 h; Group GEL = 58.46 h; P = 0.949) and Grade II (Group QPS = 62.4 h; Group GEL = 61.17 h; P = 0.732) phlebitis was comparable no adverse effects were reported in either group.CONCLUSION: Heparin QPS was more effective in he prevention of infusion‑associated phlebitis with similar safety profile as heparin gel.
650		0	_94774 _aPHARMACOLOGY
653			_aHeparin
653			_aQuick penetrating topical solution
653			_aSuperficial thrombophlebitis
700			_98216 _aTanvir Samra
700			_98217 _aAhuja, Nitin
773	0		_x0253-7613 _dAndheri - Mumbai Wolters Kluwer India Private Limited _tIndian Journal of Pharmacology
856			_uhttp://www.ijp-online.com/temp/IndianJPharmacol506344-1434046_035900.pdf _yClick here
942			_2ddc _cAR