000			a
999			_c9040 _d9040
003			OSt
005			20190520103302.0
008			190520b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_96961 _aRavishankar, K.
245			_aComparative evaluation of in vitro antioxidant and in vivo hepatooprotective activities of ethanolic leaf and root extracts of cleome gynandra
250			_aVol. 56(04), April
260			_aMumbai _bIndian Drug Manufacturers Association _c2019
300			_a50-56p.
520			_aIn vitro antioxidant and in vivo hepatoprotective activities of Cleome gynandra ethanolic leaf and root extracts were assessed. In vitro antioxidant activity was carried by DPPH, Nitric oxide, hydroxyl radical and phosphomolybdenum assays. Hepatoprotective activity was evaluated by Carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats.The animals were divided into seven groups (Four test groups - Ethanolic Leaf and Root Extracts of Cleome gynandra of 100 mg/kg and 200 mg/kg, standard silymarin (100 mg/kg), toxic control-carbon tetrachloride and vehicle). On the eight day, the blood was collected and parameters like serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), Alkaline phosphatase (ALP) and Total bilirubin (TB) were estimated. Significant antioxidant status with good IC50 values similar to standard ascorbic acid was obtained. A significant decrease in liver enzymes was observed in test groups comparable to silymarin. From the results obtained, ethanolic leaf extract has contributed better hepatoprotection compared with root extract in experimental rats.
650		0	_95021 _aDRUG STORE MANAGEMENT
700			_98628 _aLakshmi Prasanna, Y. V. V. M.
700			_96962 _aKiranmayi, G. V. N.
773	0		_tIndian drugs _dMumbai Indian Drug Manufactures Association
856			_uhttps://www.indiandrugsonline.org/issuesarticle-details?id=OTIz _yClick here
942			_2ddc _cAR