000			a
999			_c9137 _d9137
003			OSt
005			20190529113748.0
008			190529b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_98921 _aAkula, Venkatakrishna
245			_aStability Indicating HPLC Method using Core Shell Stationary Phase for the Determination of Related Substances in Levocetirizine Dihydrochloride Oral Solution
250			_aVol. 52(4), Oct-Dec
260			_aBengaluru _bAssociation of Pharmaceutical Teachers of India (APTI) _c2018
300			_a684-690p.
520			_antroduction: Levocetirizine (LCZ) is a new generation antihistamine drug used for the allergic symptoms resulting from various diseases. The present research work focuses on the development of a simple and precise HPLC method for the effective separation and quantitative determination of LCZ and its impurities. Objectives: Eight potential related impurities of LCZ were separated and identified in the bulk drug as well as oral solution dosage form. Results: The separation was achieved on a core shell stationary phase Kinetex bipheyl (250, 4.6×5 μm) column with mobile phase of sodium perchlorate in water and acetonitrile in a gradient elution. The results were monitored and analytes were quantified at 230 nm. Conclusion: The proposed method was stability indicating and was validated as per ICH guidelines for specificity, linearity, precision, accuracy and robustness. The proposed method finds its application in the routine analysis of LCZ in bulk drug and various dosage forms
650		0	_94639 _aPHARMACEUTICS
700			_98922 _aSinha, Barij Nayan
700			_98923 _aSeok, Han Jeong
773	0		_dBengluru Association of Pharmaceutical Teachers of India (APTI) _tIndian journal of pharmaceutical education and research _x0019-5464
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_52_4_684_0.pdf _yClick here
942			_2ddc _cAR