| 000 | a | ||
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| 999 |
_c9623 _d9623 |
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| 003 | OSt | ||
| 005 | 20191007144910.0 | ||
| 008 | 191007b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_99759 _aJalundhwala, Forum |
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| 245 | _aNovel oral delivery of ibuprofen solution in hard gelatin capsules | ||
| 250 | _aVol. 11 (06) | ||
| 260 |
_aBhopal _bInnovare Academic Sciences Pvt Ltd _c2019 |
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| 300 | _a50-55 | ||
| 520 | _aThe primary objective of the project was to formulate and evaluate hard capsule containing the solution of ibuprofen. It also included enhancement of solubility of ibuprofen in hydrophilic solvents to obtain a unit dose capsule acceptable for human consumption. Methods: Solution of ibuprofen was developed by the salt formation of partial drug using potassium hydroxide in PEG 600 and water. The solution was encapsulated in hard capsules with band sealing. The final formulation was evaluated for uniformity of weight, disintegration, drug content and stability. The dissolution profile was compared with that of available marketed tablets and softgels. Results: The capsules were evaluated and found compliant as per specifications mentioned in general monograph of capsules in IP 2014. The uniformity of weight of the batch of capsules was found to be 734.8 mg (±0.58). The disintegration time of these capsules was observed to be 4.45 min. The drug content was found to be 100.03% and the product is stable over three months of test period under room temperature as well as accelerated conditions. The dissolution profile showed that softgels take longer time to release the drug whereas marketed tablets showed a dissolution profile comparable with that of formulated capsules. Conclusion: The developed capsule is a unit dose of liquid containing solubilized ibuprofen delivering the drug directly into the gastrointestinal tract (GIT). These are newer solid oral dosage forms with higher patient compliance and ease in manufacturing. They require lesser steps and manufacturing area when compared to the manufacturing of compressed tablets. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_99760 _aLondhe, Vaishali |
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| 773 | 0 |
_tInternational journal of pharmacy and pharmaceutical science _x0975 – 1491 _dBhopal Innovare Academic Sciences Pvt Ltd |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/32659 _yClick here |
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| 942 |
_2ddc _cAR |
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