| 000 | a | ||
|---|---|---|---|
| 999 |
_c9778 _d9778 |
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| 003 | OSt | ||
| 005 | 20191019102129.0 | ||
| 008 | 191019b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_99975 _aWang, Yonglu |
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| 245 | _aPharmacokinetics and Tissue Distribution of PLGA-PLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS | ||
| 250 | _aVol.52(1), Jan-Mar | ||
| 260 |
_aKarnataka _bIndian journal of pharmaceutical education and research _c2018 |
||
| 300 | _a42-53p. | ||
| 520 | _aObjective: A sensitive, rapid and reliable LC-MS/MS method was developed for simultaneously determination of daunorubicin (DNR) and tetrandrine (Tet) in rat plasma and tissues. Methods: The pharmacokinetics and tissue distribution of DNR/Tet-PLGA-PLL-PEG-NPs-Tf (D/T-PPP-NPs-Tf), DNR/Tet-PLGA-PLL-PEG-NPs (D/T-PPP-NPs) and DNR/Tet (D/T) solution were compared following intravenous injection in the rats. Result: Compare to D/T solution, the parameters of DNR and Tet in D/T-PPP-NPs-Tf group presented significantly higher AUC (p<0.01) and lower V (p<0.05). Compared with D/T solution, the distribution of DNR in groups of D/T-PPP-NPs and D/T-PPP-NPs-Tf were higher in liver (p<0.01), lung (p<0.05), fat (p<0.05) and testicle (p<0.05), and were lower in heart, spleen, kidney (p<0.01), brain and intestine (p<0.01). The distribution of Tet in D/T-PPP-NPs and D/T-PPP-NPs-Tf groups were higher in liver, brain and uterus (p<0.05), and were lower in heart, spleen, lung, kidney and fat (p<0.05) compared with D/T solution. Conclusion: The LC-MS/MS method was specific, sensitive, rapid and reliable for the simultaneously determination of DNR and Tet in rat plasma and tissues. Compared with D/T solution, D/T-PPP-NPs-Tf tended to stay in the blood after injection. The distribution of D/T-PPP-NPs and D/T-PPP-NPs-Tf were significantly changed. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
|
| 700 |
_99976 _aLi, Yang |
||
| 773 | 0 |
_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research |
|
| 856 |
_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_52_1_42.pdf _yClick here |
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| 942 |
_2ddc _cAR |
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