000			a
999			_c9783 _d9783
003			OSt
005			20191019112629.0
008			191019b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_99987 _aChandra, Yadala Prapurna
245			_aChemo Preventive Effect of Rutin Against N-Nitrosodiethylamine-Induced and Phenobarbital-Promoted Hepatocellular Carcinoma in Wistar Rats
250			_aVol.52(1), Jan-Mar
260			_aKarnataka _bIndian journal of pharmaceutical education and research _c2018
300			_a78-86p.
520			_aBackground: In recent years, a large number of natural compounds have been identified and proved to have a potential cancer chemopreventive importance due to their strong antioxidant and cytotoxic activities. Objective: The present study is designed to investigate the preventive effects of Rutin against N-Nitrosodiethylamine-induced and Phenobarbital-promoted Hepatocellular carcinoma in male wistar rats. Materials and Methods: Twenty-four male wistar rats were divided into four groups (n=6). Group I serve as Control, Group II was induced HCC by DEN (200mg/kg b.wt) followed by phenobarbital (0.05 % w/v), Group III received same as Group II and followed by Rutin (50mg/kg b.wt) and Group IV received Rutin alone at a dose of 50mg/kg b.wt, up to 16 successive weeks. Results: Results observed that there is significant increase in relative liver weight and liver marker enzymes (P<0.001), tumor marker enzymes (AFP, CEA at P<0.001) and also Significant abnormalities were observed in membrane bound enzymes and Electrolytes, whereas the above said alterations were significantly restored in Rutin treated group compared with DEN treated Group. Conclusion: The results of these findings suggested that Rutin can be used as an adjunct to conventional chemopreventive agent, which may provide a novel therapeutic approach to serve as a promising agent for treatment of Hepatocellular carcinoma
650		0	_94639 _aPHARMACEUTICS
700			_99988 _aViswanathswamy, A.H.M.
773	0		_dBengluru Association of Pharmaceutical Teachers of India (APTI) _tIndian journal of pharmaceutical education and research _x0019-5464
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_52_1_78.pdf _yClick here
942			_2ddc _cAR