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| 999 |
_c9784 _d9784 |
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| 003 | OSt | ||
| 005 | 20191019114132.0 | ||
| 008 | 191019b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_99989 _aDas, Barnali |
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| 245 | _aDuration dependent antiapoptotic efficacy of camellia sinensis (green tea) on streptozotocin induced diabetes linked testicular hypofunction in albino rat: genomic and flow cytometric assessment | ||
| 250 | _aVol. 11 (06) | ||
| 260 |
_aBhopal _bInnovare Academic Sciences Pvt Ltd _c2019 |
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| 300 | _a85-93 | ||
| 520 | _aThe study has been conducted to search out the threshold duration of treatment of ethyl acetate fraction of methanolic extract of leaves of Camellia sinensis (L.) Kuntze at the dose of 100 mg/kg body weight for the management of diabetes-induced testicular impairment in streptozotocin-induced diabetic rat in a duration dependent fashion. Methods: In this respect, the glycemic, androgenic, oxidative stress sensors, gene expression of testicular androgenic key enzymes along with apoptotic markers were evaluated in a duration dependent way (14, 28 and 56 d). Results: A significant correction was noted in the levels of glycated haemoglobin (HbA1C), testicular thiobarbituric acid reactive substances (TBARS), conjugated diene (CD), sperm viability, sperm mitochondrial status, serum testosterone, and genomic expression of testicular Δ5, 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD, Bax, Bcl-2 after treatment for different duration with the said fraction in diabetic groups in compare to respective vehicle-treated diabetic group without any toxicity induction in general. Thin layer chromatography (TLC) study of the fraction showed two spots with retention factors (Rf) of 0.78 and 0.51. Conclusion: The results showed that 28 d treatment was threshold duration of treatment for the correction of diabetes-induced testicular impairment. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_99991 _aBiswas, Baisakhi |
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| 773 | 0 |
_tInternational journal of pharmacy and pharmaceutical science _dBhopal Innovare Academic Sciences Pvt Ltd _x2656-0097 |
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| 856 |
_uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/31150 _yClick here |
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| 942 |
_2ddc _cAR |
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