| 000 | a | ||
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_c9790 _d9790 |
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| 003 | OSt | ||
| 005 | 20191019132108.0 | ||
| 008 | 191019b xxu||||| |||| 00| 0 eng d | ||
| 040 |
_aAIKTC-KRRC _cAIKTC-KRRC |
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| 100 |
_910001 _aChennapragada, Krishna Prasad |
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| 245 | _aSynthesis and Characterization of 2-phenyl-5-(1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl) - 1, 3, 4-oxadiazole Scaffolds for Assessing Their Medicinal Potentials | ||
| 250 | _aVol.52(1), Jan-Mar | ||
| 260 |
_aKarnataka _bIndian journal of pharmaceutical education and research _c2018 |
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| 300 | _a135-145p. | ||
| 520 | _aObjective: The present research is aimed at the discovery and development of 1-phenyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole derivatives as a series of novel 1, 3, 4-oxadiazoles (7a-7h) through iodine-catalyzed oxidative cyclization of the hydrazone derivatives (6a-6h) in the presence of potassium carbonate as base and DMSO as solvent in good toexcellent yields. Methods: The structures of all the newly synthesized compounds (6a-6h) and(7a-7h) were well characterized by IR, 1H NMR, 13C NMR and HRMS. Furthermore, allthe synthesized compounds (6a-6h and 7a-7h) were evaluated for their antimicrobial andanti-oxidant activities. Results: The research results revealed that the compound 6d (Z)-2-bromo-N'-((1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl) methylene) benzohydrazide) has antimicrobial potent while the synthesized compounds 6a (Z)-N'-((1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl) methylene) benzohydrazide), 6e (Z)-2, 5-dichloro-N'-((1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl) methylene) benzohydrazide), 7e (2-(2, 5-dichlorohenyl)-5-(1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl)-1, 3, 4-oxadiazole) and 7f (2-(3, 5-dichlorophenyl)-5-(1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl)-1, 3, 4-oxadiazole) exhibited strong antioxidant activity compared to the control BHT. Conclusion: The novel hydrazonessynthesized and 1, 3, 4 oxadiazole derivatives may be suggested for their establishment in chemical class of antimicrobial and antioxidant agents in new drug discovery and medicinal research. | ||
| 650 | 0 |
_94639 _aPHARMACEUTICS |
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| 700 |
_910002 _aPalagummi, Venkata Sathya Machiraju |
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| 773 | 0 |
_dBengluru Association of Pharmaceutical Teachers of India (APTI) _x0019-5464 _tIndian journal of pharmaceutical education and research |
|
| 856 |
_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_52_1_135.pdf _yClick here |
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| 942 |
_2ddc _cAR |
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