000			a
999			_c9791 _d9791
003			OSt
005			20191019141922.0
008			191019b xxu||||| |||| 00| 0 eng d
040			_aAIKTC-KRRC _cAIKTC-KRRC
100			_910003 _aVasovic, Velibor
245			_aEffect of Aminophylline on Quinidine Passage into the Central Nervous System of Rats
250			_aVol.52(1), Jan-Mar
260			_aKarnataka _bIndian journal of pharmaceutical education and research _c2018
300			_a146-150p.
520			_aBackground and Objective: There is significant interest in mutual influence of substances during their passage into the central nervous system (CNS). Quinidine is a drug which can achieve significant concentration in CNS and cause side effects and aminophylline is a drug with possibility to change distribution of drugs in CNS. Thus the aim of this work was to study the effect of aminophylline on the transition of quinidine through the blood-brain barrier into the central nervous system. Material and Methods: The experiments were carried out on Wistar rats, which received quinidine in the form of the retrograde intra-arterial bolus injection into the right axillary vein. The control group of animals received subcutaneously physiological solution 30 min before the intra-arterial quinidine application, whereas the test group animals also received subcutaneously aminophylline 30 min before quinidine application. The rats were sacrificed by decapitation in specified time intervals in order to determine quinidine concentration in different parts of CNS. Results: There were no significant changes in serum quinidine levels by comparing the results of experimental group with those of the control group of animals. In all parts of CNS aminophylline pre-treatment caused significant decrease in CNS quinidine concentration. Conclusion: The results suggest that co-administration of aminophylline and quinidine, decreases quinidine concentrations in the CNS of rats
650		0	_94639 _aPHARMACEUTICS
700			_910004 _aStilinovic, Nebojsa
773	0		_x0019-5464 _tIndian journal of pharmaceutical education and research _dBengluru Association of Pharmaceutical Teachers of India (APTI)
856			_uhttps://www.ijper.org/sites/default/files/IndJPhaEdRes_52_1_146.pdf _yClick here
942			_2ddc _cAR