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999 _c9861
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040 _aAIKTC-KRRC
_cAIKTC-KRRC
100 _910132
_aRajeswari, Saripilli
245 _aFormulation and evaluation of famotidine fast dissolving tablets using synthetic superdisintegrants
250 _aVol. 11(8)
260 _aBhopal
_bInnovare Academic Sciences Pvt Ltd
_c2019
300 _a17-25
520 _aObjective: The main aim of the present research work was to formulate fast dissolving tablets of famotidine by direct compression method and to evaluate the effect of synthetic super disintegrating agent on drug release pattern. Methods: The fast dissolving tablets were prepared by using crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants (2, 4 and 6 %w/w), mannitol 20 % and microcrystalline cellulose (44, 46 and 48 % w/w) as a directly compressible vehicle. All the prepared tablets were evaluated for hardness, friability, drug content uniformity, weight variation, disintegrating time, wetting time and in vitro drug release studies. Results: All the prepared fast dissolving tablets formulations were within the Pharmacopoeial standards limits. Based on in vitro drug release studies (>90 % within 30 min), the optimised formulations were optimised tested for the short term stability (at 40 ˚C/75% RH for 3 mo) and drug excipient interaction (fourier transform infrared spectroscopy). Conclusion: Hence, formulation prepared with 6 % w/w of crosspovidine and 44 % w/w of microcrystalline cellulose as emerged as the overall best formulation (>90 % within 30 min) compared to marketed product (>70 % within 30 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro drug release (p<0.05). Keywords: Famotidine, Croscarmellose sodium, Crosspovidine, Sodium starch Glycolate, Fast dissolving tablets
650 0 _94639
_aPHARMACEUTICS
700 _910133
_aKumari, M. Yerni
773 0 _aSai, Ashwini R.
_dBhopal Innovare Academic Sciences Pvt Ltd 2019
_tAnalysis of applicability of tools of inventory control and knowledge of hospital pharmacists on methods of inventory in the central pharmacy of a tertiary care hospital
856 _uhttps://innovareacademics.in/journals/index.php/ijpps/article/view/33175
_yClick here
942 _2ddc
_cAR