Tiwari, Anshuly
SYNTHESIS AND ANTICANCER SCREENING OF TRIAZINE ANAL OGUES - Vol.11(4) - M P Innovare Academic Sciences Pvt Ltd 2019 - 114-121p.
Objective:
The study was aimed to investigate the cytotoxic ef
fect of
S-5H
-[1,2,4]-triazino (5,6-
b
) indol-3-yl-3,4-phenylethane-thioate derivatives a
s
epidermal growth factor Receptor (EGFR) inhibitors.
Methods:
In the present study 14 novel triazine analogues we
re synthesized and characterized using different sp
ectroscopic techniques such as FT-
IR, NMR and Mass Spectroscopy. The anticancer activ
ity was performed using MCF-7 (breast cancer) and K
-562 (leukaemia) cell lines. Further,
molecular docking was carried out using Vlife Molec
ular Docking Software (MDS) on crystal structure of
epidermal growth factor receptor (EGFR)
to identify the binding mode of interaction with an
active site.
Results:
Compounds MA-7, MA-8, MA-12, MA-13 and MA-14 show p
otent activity against cancer cell lines in the ran
ge of<10 to 84.4 μg/ml. Further
molecular docking on EGFR also supports that there
is a strong correlation between
in silico
and
in vitro
biological activity. The results of this study
may be further useful for lead optimization process
.
PHARMACEUTICS
SYNTHESIS AND ANTICANCER SCREENING OF TRIAZINE ANAL OGUES - Vol.11(4) - M P Innovare Academic Sciences Pvt Ltd 2019 - 114-121p.
Objective:
The study was aimed to investigate the cytotoxic ef
fect of
S-5H
-[1,2,4]-triazino (5,6-
b
) indol-3-yl-3,4-phenylethane-thioate derivatives a
s
epidermal growth factor Receptor (EGFR) inhibitors.
Methods:
In the present study 14 novel triazine analogues we
re synthesized and characterized using different sp
ectroscopic techniques such as FT-
IR, NMR and Mass Spectroscopy. The anticancer activ
ity was performed using MCF-7 (breast cancer) and K
-562 (leukaemia) cell lines. Further,
molecular docking was carried out using Vlife Molec
ular Docking Software (MDS) on crystal structure of
epidermal growth factor receptor (EGFR)
to identify the binding mode of interaction with an
active site.
Results:
Compounds MA-7, MA-8, MA-12, MA-13 and MA-14 show p
otent activity against cancer cell lines in the ran
ge of<10 to 84.4 μg/ml. Further
molecular docking on EGFR also supports that there
is a strong correlation between
in silico
and
in vitro
biological activity. The results of this study
may be further useful for lead optimization process
.
PHARMACEUTICS