SYNTHESIS AND ANTICANCER SCREENING OF TRIAZINE ANAL OGUES (Record no. 11186)
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200212104412.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200212b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12133 |
| Author | Tiwari, Anshuly |
| 245 ## - TITLE STATEMENT | |
| Title | SYNTHESIS AND ANTICANCER SCREENING OF TRIAZINE ANAL OGUES |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.11(4) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 114-121p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: The study was aimed to investigate the cytotoxic ef fect of S-5H -[1,2,4]-triazino (5,6- b ) indol-3-yl-3,4-phenylethane-thioate derivatives a s epidermal growth factor Receptor (EGFR) inhibitors. Methods: In the present study 14 novel triazine analogues we re synthesized and characterized using different sp ectroscopic techniques such as FT- IR, NMR and Mass Spectroscopy. The anticancer activ ity was performed using MCF-7 (breast cancer) and K -562 (leukaemia) cell lines. Further, molecular docking was carried out using Vlife Molec ular Docking Software (MDS) on crystal structure of epidermal growth factor receptor (EGFR) to identify the binding mode of interaction with an active site. Results: Compounds MA-7, MA-8, MA-12, MA-13 and MA-14 show p otent activity against cancer cell lines in the ran ge of<10 to 84.4 μg/ml. Further molecular docking on EGFR also supports that there is a strong correlation between in silico and in vitro biological activity. The results of this study may be further useful for lead optimization process . |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 12134 |
| Co-Author | Modi, Siddharth J. |
| 773 0# - HOST ITEM ENTRY | |
| Title | International journal of pharmacy and pharmaceutical science |
| International Standard Serial Number | 2656-0097 |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/28275/19679 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2020-02-12 | 2020919 | 2020-02-12 | 2020-02-12 | Articles Abstract Database |