Yanchun, Z.
Protective effect of ipomoea staphylina against cadmium-induced cardiotoxicity in wistar rats - Vol.83(1), Jan-Feb - Mumbai Indian Journal of Pharmaceutical Science 2021 - 93-100p.
The present study was aimed to evaluate the protective effect of ethanolic extract of Ipomoea staphylina
leaves against cadmium-induced cardiotoxicity in rats. Rats were segregated into four groups which
included normal control, cadmium treated, Cd+ Ipomoea staphylina (200 mg/kg) treated, and Cd+ Ipomoea
staphylina (400 mg/kg) treated. The cadmium treatment resulted in a signi ficant increase in the activities
of lactate dehydrogenase, creatine phosphokinase, serum glutamic oxaloacetic transaminase and serum
glutamic pyruvic transaminase. Also, a signi ficant increase in the levels of cholesterol, triglycerides,
and low-density lipoprotein was noticed after cadmium treatment. On the other hand, high-density
lipoprotein was significantly decreased following cadmium treatment. A signi ficant decline in the activity
of antioxidant enzymes was observed in cadmium intoxicated rats. Moreover, cadmium intoxicated rats
resulted in signi ficant increase in the levels of proin flammatory cytokines such as tumor necrosis factor
alpha, interleukin 1 beta, and nitric oxide in the cardiac tissue. Supplementation of Ipomoea staphylina
leaves extract to cadmium treated rats reversed most of the indices. The extract (400 mg/kg) revealed better
protective effects by decreasing the activities of lactate dehydrogenase, creatine phosphokinase, serum
glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase and improving the lipid
profile. Besides, the extract also signi ficantly improved the antioxidant enzymes activity and decreased
the level of tumor necrosis factor alpha, interleukin 1 beta, and nitric oxide. Further, the histopathological
study of heart supported the protective effects of Ipomoea staphylina leaves extract. The study, therefore,
concludes that Ipomoea staphylina leaves extract holds a strong protective effect against cadmium-induced
cardiotoxicity in rats.
PHARMACEUTICS
Protective effect of ipomoea staphylina against cadmium-induced cardiotoxicity in wistar rats - Vol.83(1), Jan-Feb - Mumbai Indian Journal of Pharmaceutical Science 2021 - 93-100p.
The present study was aimed to evaluate the protective effect of ethanolic extract of Ipomoea staphylina
leaves against cadmium-induced cardiotoxicity in rats. Rats were segregated into four groups which
included normal control, cadmium treated, Cd+ Ipomoea staphylina (200 mg/kg) treated, and Cd+ Ipomoea
staphylina (400 mg/kg) treated. The cadmium treatment resulted in a signi ficant increase in the activities
of lactate dehydrogenase, creatine phosphokinase, serum glutamic oxaloacetic transaminase and serum
glutamic pyruvic transaminase. Also, a signi ficant increase in the levels of cholesterol, triglycerides,
and low-density lipoprotein was noticed after cadmium treatment. On the other hand, high-density
lipoprotein was significantly decreased following cadmium treatment. A signi ficant decline in the activity
of antioxidant enzymes was observed in cadmium intoxicated rats. Moreover, cadmium intoxicated rats
resulted in signi ficant increase in the levels of proin flammatory cytokines such as tumor necrosis factor
alpha, interleukin 1 beta, and nitric oxide in the cardiac tissue. Supplementation of Ipomoea staphylina
leaves extract to cadmium treated rats reversed most of the indices. The extract (400 mg/kg) revealed better
protective effects by decreasing the activities of lactate dehydrogenase, creatine phosphokinase, serum
glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase and improving the lipid
profile. Besides, the extract also signi ficantly improved the antioxidant enzymes activity and decreased
the level of tumor necrosis factor alpha, interleukin 1 beta, and nitric oxide. Further, the histopathological
study of heart supported the protective effects of Ipomoea staphylina leaves extract. The study, therefore,
concludes that Ipomoea staphylina leaves extract holds a strong protective effect against cadmium-induced
cardiotoxicity in rats.
PHARMACEUTICS