Protective effect of ipomoea staphylina against cadmium-induced cardiotoxicity in wistar rats (Record no. 15812)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211229112640.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211229b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15191 |
| Author | Yanchun, Z. |
| 245 ## - TITLE STATEMENT | |
| Title | Protective effect of ipomoea staphylina against cadmium-induced cardiotoxicity in wistar rats |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 93-100p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present study was aimed to evaluate the protective effect of ethanolic extract of Ipomoea staphylina leaves against cadmium-induced cardiotoxicity in rats. Rats were segregated into four groups which included normal control, cadmium treated, Cd+ Ipomoea staphylina (200 mg/kg) treated, and Cd+ Ipomoea staphylina (400 mg/kg) treated. The cadmium treatment resulted in a signi ficant increase in the activities of lactate dehydrogenase, creatine phosphokinase, serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase. Also, a signi ficant increase in the levels of cholesterol, triglycerides, and low-density lipoprotein was noticed after cadmium treatment. On the other hand, high-density lipoprotein was significantly decreased following cadmium treatment. A signi ficant decline in the activity of antioxidant enzymes was observed in cadmium intoxicated rats. Moreover, cadmium intoxicated rats resulted in signi ficant increase in the levels of proin flammatory cytokines such as tumor necrosis factor alpha, interleukin 1 beta, and nitric oxide in the cardiac tissue. Supplementation of Ipomoea staphylina leaves extract to cadmium treated rats reversed most of the indices. The extract (400 mg/kg) revealed better protective effects by decreasing the activities of lactate dehydrogenase, creatine phosphokinase, serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase and improving the lipid profile. Besides, the extract also signi ficantly improved the antioxidant enzymes activity and decreased the level of tumor necrosis factor alpha, interleukin 1 beta, and nitric oxide. Further, the histopathological study of heart supported the protective effects of Ipomoea staphylina leaves extract. The study, therefore, concludes that Ipomoea staphylina leaves extract holds a strong protective effect against cadmium-induced cardiotoxicity in rats. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15192 |
| Co-Author | Xue, Jin |
| 773 0# - HOST ITEM ENTRY | |
| Title | Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication | New Delhi |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/protective-effect-of-emipomoea-staphylinaem-against-cadmiuminduced-cardiotoxicity-in-wistar-rats.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2021-12-29 | 2021-2022629 | 2021-12-29 | 2021-12-29 | Articles Abstract Database |