Jacques, Akpa Sagne
Synthesis of bis-benzimidazoles n-alkyl anti-infectious derivates - Vol.13(6) - M P Innovare Academic Sciences Pvt Ltd 2021 - 52-55p.
Objective:The objective of this work is to synthesize new molecules with biological characteristics against some infectious germs. Methods:The method of synthesis is based on the exploitation of the reactivity of the position-1 of the benzimidazole.It consisted ofreactingthe bis-benzimidazole 5 with the 1,2-dicloroethane in a solution of NaOH 2N (6,4%). The compound 6 is refluxed with ethanol with the different thioaryls to lead to compounds 7. Results:Thus, a series of molecules derived from bis-benzimidazoles were synthesized including N-alkylated 6 and 7a-d. The characterization of these newly synthesized compounds was performed by NMR (1H and 13C) and mass spectroscopy methods. Conclusion: The purified and characterized compounds 6 and 7a-d allow the development of a new chemical class of anti-infectives.
PHARMACEUTICS
Synthesis of bis-benzimidazoles n-alkyl anti-infectious derivates - Vol.13(6) - M P Innovare Academic Sciences Pvt Ltd 2021 - 52-55p.
Objective:The objective of this work is to synthesize new molecules with biological characteristics against some infectious germs. Methods:The method of synthesis is based on the exploitation of the reactivity of the position-1 of the benzimidazole.It consisted ofreactingthe bis-benzimidazole 5 with the 1,2-dicloroethane in a solution of NaOH 2N (6,4%). The compound 6 is refluxed with ethanol with the different thioaryls to lead to compounds 7. Results:Thus, a series of molecules derived from bis-benzimidazoles were synthesized including N-alkylated 6 and 7a-d. The characterization of these newly synthesized compounds was performed by NMR (1H and 13C) and mass spectroscopy methods. Conclusion: The purified and characterized compounds 6 and 7a-d allow the development of a new chemical class of anti-infectives.
PHARMACEUTICS