Synthesis of bis-benzimidazoles n-alkyl anti-infectious derivates
By: Jacques, Akpa Sagne
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Contributor(s): Diomande, Gbe Gondo Didier.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2021Edition: Vol.13(6).Description: 52-55p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:The objective of this work is to synthesize new molecules with biological characteristics against some infectious germs. Methods:The method of synthesis is based on the exploitation of the reactivity of the position-1 of the benzimidazole.It consisted ofreactingthe bis-benzimidazole 5 with the 1,2-dicloroethane in a solution of NaOH 2N (6,4%). The compound 6 is refluxed with ethanol with the different thioaryls to lead to compounds 7. Results:Thus, a series of molecules derived from bis-benzimidazoles were synthesized including N-alkylated 6 and 7a-d. The characterization of these newly synthesized compounds was performed by NMR (1H and 13C) and mass spectroscopy methods. Conclusion: The purified and characterized compounds 6 and 7a-d allow the development of a new chemical class of anti-infectives.
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022652 |
Objective:The objective of this work is to synthesize new molecules with biological characteristics against some infectious germs. Methods:The method of synthesis is based on the exploitation of the reactivity of the position-1 of the benzimidazole.It consisted ofreactingthe bis-benzimidazole 5 with the 1,2-dicloroethane in a solution of NaOH 2N (6,4%). The compound 6 is refluxed with ethanol with the different thioaryls to lead to compounds 7. Results:Thus, a series of molecules derived from bis-benzimidazoles were synthesized including N-alkylated 6 and 7a-d. The characterization of these newly synthesized compounds was performed by NMR (1H and 13C) and mass spectroscopy methods. Conclusion: The purified and characterized compounds 6 and 7a-d allow the development of a new chemical class of anti-infectives.
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