Tamilarasan, B.
Synthesis, characterisation and biological study of pyrazolino and isoxazolo cycloocta[b]indole derivatives - Vol.58(B), Jan. - New Delhi CSIR 2019 - 96-103p.
An efficient route for the synthesis and study of biological activity of eight membered indole fused compounds has been found by employing methyl-benzaldehyde to condense with a precursor cycloocta[b]indole derivative to give condensed product namely, 2-(4'-methyl-benzylidene)-1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole 3. Using 3, further compounds have been prepared namely, pyrazolinocycloocta[b]indole and isoxazolocycloocta[b]indole derivatives by allowing the condensed product to react with hydrazine hydrate and hydroxylamine hydrochloride, which results in the formation of 3-(4'-methyl-phenyl)-4,5,6,7-tetrahydro-2H-pyrazolino[4',5':7,8]cycloocta[b]indoles 4 and 3-(4'-methyl-phenyl)-4,5,6,7-tetrahydroisoxazolo[4',3':7,8]cycloocta[b]indoles 5. Their biological activities have been studied against bacterial and fungal strains.
GENERAL CHEMISTRY
Synthesis, characterisation and biological study of pyrazolino and isoxazolo cycloocta[b]indole derivatives - Vol.58(B), Jan. - New Delhi CSIR 2019 - 96-103p.
An efficient route for the synthesis and study of biological activity of eight membered indole fused compounds has been found by employing methyl-benzaldehyde to condense with a precursor cycloocta[b]indole derivative to give condensed product namely, 2-(4'-methyl-benzylidene)-1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole 3. Using 3, further compounds have been prepared namely, pyrazolinocycloocta[b]indole and isoxazolocycloocta[b]indole derivatives by allowing the condensed product to react with hydrazine hydrate and hydroxylamine hydrochloride, which results in the formation of 3-(4'-methyl-phenyl)-4,5,6,7-tetrahydro-2H-pyrazolino[4',5':7,8]cycloocta[b]indoles 4 and 3-(4'-methyl-phenyl)-4,5,6,7-tetrahydroisoxazolo[4',3':7,8]cycloocta[b]indoles 5. Their biological activities have been studied against bacterial and fungal strains.
GENERAL CHEMISTRY