Synthesis, characterisation and biological study of pyrazolino and isoxazolo cycloocta[b]indole derivatives
By: Tamilarasan, B
.
Contributor(s): Sangeetha, V.
Publisher: New Delhi CSIR 2019Edition: Vol.58(B), Jan.Description: 96-103p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: An efficient route for the synthesis and study of biological activity of eight membered indole fused compounds has been found by employing methyl-benzaldehyde to condense with a precursor cycloocta[b]indole derivative to give condensed product namely, 2-(4'-methyl-benzylidene)-1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole 3. Using 3, further compounds have been prepared namely, pyrazolinocycloocta[b]indole and isoxazolocycloocta[b]indole derivatives by allowing the condensed product to react with hydrazine hydrate and hydroxylamine hydrochloride, which results in the formation of 3-(4'-methyl-phenyl)-4,5,6,7-tetrahydro-2H-pyrazolino[4',5':7,8]cycloocta[b]indoles 4 and 3-(4'-methyl-phenyl)-4,5,6,7-tetrahydroisoxazolo[4',3':7,8]cycloocta[b]indoles 5. Their biological activities have been studied against bacterial and fungal strains.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0290 |
An efficient route for the synthesis and study of biological activity of eight membered indole fused compounds has been found by employing methyl-benzaldehyde to condense with a precursor cycloocta[b]indole derivative to give condensed product namely, 2-(4'-methyl-benzylidene)-1-oxo-1,2,3,4,5,6-hexahydrocycloocta[b]indole 3. Using 3, further compounds have been prepared namely, pyrazolinocycloocta[b]indole and isoxazolocycloocta[b]indole derivatives by allowing the condensed product to react with hydrazine hydrate and hydroxylamine hydrochloride, which results in the formation of 3-(4'-methyl-phenyl)-4,5,6,7-tetrahydro-2H-pyrazolino[4',5':7,8]cycloocta[b]indoles 4 and 3-(4'-methyl-phenyl)-4,5,6,7-tetrahydroisoxazolo[4',3':7,8]cycloocta[b]indoles 5. Their biological activities have been studied against bacterial and fungal strains.
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