Shrivastava, Aman
Therapeutic approaches of nanotechnology for epileptic seizures: a comprehensive review of current knowledge - Vol.56(3), Jul-Sep - Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022 - 628-635p.
Epilepsy is a chronic neurological condition in which several neurotransmitters act like
neuromodulators. The symptoms of epilepsy are caused by abnormal electrical discharges
in a group of neurons in the hippocampus region of the brain. This can also affect electrical
impulse generation, either in the focal area or in the hippocampus region of the brain. This
review aimed to develop a better understanding of the transportation of nanoparticles
across the blood-brain barrier and how to enhance the delivery of the drug in epileptic
conditions by the utilization of nanomaterials. A few clinical studies have reported that
antiepileptic drugs are generally used for the treatment of epilepsy by decreasing the
frequency and intensity of seizures or preventing tissue damage in the brain. In long-
term therapy, antiepileptic drugs are primarily administered via the oral route, but they
are not always beneficial. Therefore, intravenous routes are especially used in serious
epileptic conditions. In this review, we discussed the drug delivery study of antiepileptic
drugs that are used in the form of nanoparticles that can easily be transported across the
blood-brain barrier. Besides, the nanoparticles can easily cross the blood-brain barrier and
increase the uptake into the target cells. Drug absorption into the brain is substantially
limited by some factors, especially in the blood-brain barrier, which affects the potency
of antiepileptic drugs to reach and remain inside the brain. Novel drug delivery systems
have already been studied in many clinical trials to enhance the therapeutic efficacy of
antiepileptic drugs in epileptic conditions.
PHARMACEUTICS
Therapeutic approaches of nanotechnology for epileptic seizures: a comprehensive review of current knowledge - Vol.56(3), Jul-Sep - Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022 - 628-635p.
Epilepsy is a chronic neurological condition in which several neurotransmitters act like
neuromodulators. The symptoms of epilepsy are caused by abnormal electrical discharges
in a group of neurons in the hippocampus region of the brain. This can also affect electrical
impulse generation, either in the focal area or in the hippocampus region of the brain. This
review aimed to develop a better understanding of the transportation of nanoparticles
across the blood-brain barrier and how to enhance the delivery of the drug in epileptic
conditions by the utilization of nanomaterials. A few clinical studies have reported that
antiepileptic drugs are generally used for the treatment of epilepsy by decreasing the
frequency and intensity of seizures or preventing tissue damage in the brain. In long-
term therapy, antiepileptic drugs are primarily administered via the oral route, but they
are not always beneficial. Therefore, intravenous routes are especially used in serious
epileptic conditions. In this review, we discussed the drug delivery study of antiepileptic
drugs that are used in the form of nanoparticles that can easily be transported across the
blood-brain barrier. Besides, the nanoparticles can easily cross the blood-brain barrier and
increase the uptake into the target cells. Drug absorption into the brain is substantially
limited by some factors, especially in the blood-brain barrier, which affects the potency
of antiepileptic drugs to reach and remain inside the brain. Novel drug delivery systems
have already been studied in many clinical trials to enhance the therapeutic efficacy of
antiepileptic drugs in epileptic conditions.
PHARMACEUTICS