Patil, Moreshwar
Application of central composite design for development of celecoxib loaded lipospheres:formulation and In-vitro characterization - Vol.56(2), Apr-June - Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022 - 405-413p.
Background: This study was initiated to develop celecoxib lipospheres to provide
controlled release. It demonstrates the use of central composite design for optimization of
liposphere formulation with less number of experiments. The development of formulation
is primarily based on poor water solubility, low bioavailability and side effects associated
with prolonged administration of celecoxib. Methods: Lipospheres were developed by melt
dispersion technique and the effect of amount of ethyl oleate and phospholipon 80H on %
entrapment
in-vitro drug release was studied using central composite design. Additionally
the lipospheres were evaluated for percentage yield, particle size and zeta potential.
Differential scanning calorimetry, x-ray diffractometry and scanning electron microscopy
was used to identify the melting state, internal structure and surface morphology. Results:
Entrapment efficiency of 73.63% was obtained while about 82.51% drug was released.
The average particle size was 35μm with homogenously dispersed particles. Celecoxib
was found to be completely miscible in lipids with disappearance of crystallinity. The
lipospheres were spherical in shape with smooth outer surface. Conclusion: Prolonged
release celecoxib lipospheres were developed using central composite design.
PHARMACEUTICS
Application of central composite design for development of celecoxib loaded lipospheres:formulation and In-vitro characterization - Vol.56(2), Apr-June - Karnataka Association of Pharmaceutical Teachers of India (APTI) 2022 - 405-413p.
Background: This study was initiated to develop celecoxib lipospheres to provide
controlled release. It demonstrates the use of central composite design for optimization of
liposphere formulation with less number of experiments. The development of formulation
is primarily based on poor water solubility, low bioavailability and side effects associated
with prolonged administration of celecoxib. Methods: Lipospheres were developed by melt
dispersion technique and the effect of amount of ethyl oleate and phospholipon 80H on %
entrapment
in-vitro drug release was studied using central composite design. Additionally
the lipospheres were evaluated for percentage yield, particle size and zeta potential.
Differential scanning calorimetry, x-ray diffractometry and scanning electron microscopy
was used to identify the melting state, internal structure and surface morphology. Results:
Entrapment efficiency of 73.63% was obtained while about 82.51% drug was released.
The average particle size was 35μm with homogenously dispersed particles. Celecoxib
was found to be completely miscible in lipids with disappearance of crystallinity. The
lipospheres were spherical in shape with smooth outer surface. Conclusion: Prolonged
release celecoxib lipospheres were developed using central composite design.
PHARMACEUTICS