Application of central composite design for development of celecoxib loaded lipospheres:formulation and In-vitro characterization (Record no. 17357)
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| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220829111442.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220829b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17651 |
| Author | Patil, Moreshwar |
| 245 ## - TITLE STATEMENT | |
| Title | Application of central composite design for development of celecoxib loaded lipospheres:formulation and In-vitro characterization |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.56(2), Apr-June |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Karnataka |
| Name of publisher, distributor, etc. | Association of Pharmaceutical Teachers of India (APTI) |
| Year | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 405-413p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: This study was initiated to develop celecoxib lipospheres to provide controlled release. It demonstrates the use of central composite design for optimization of liposphere formulation with less number of experiments. The development of formulation is primarily based on poor water solubility, low bioavailability and side effects associated with prolonged administration of celecoxib. Methods: Lipospheres were developed by melt dispersion technique and the effect of amount of ethyl oleate and phospholipon 80H on % entrapment in-vitro drug release was studied using central composite design. Additionally the lipospheres were evaluated for percentage yield, particle size and zeta potential. Differential scanning calorimetry, x-ray diffractometry and scanning electron microscopy was used to identify the melting state, internal structure and surface morphology. Results: Entrapment efficiency of 73.63% was obtained while about 82.51% drug was released. The average particle size was 35μm with homogenously dispersed particles. Celecoxib was found to be completely miscible in lipids with disappearance of crystallinity. The lipospheres were spherical in shape with smooth outer surface. Conclusion: Prolonged release celecoxib lipospheres were developed using central composite design. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 17652 |
| Co-Author | Sonawane, Diksha |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title | Indian journal of pharmaceutical education and research |
| International Standard Serial Number | 0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijper.org/sites/default/files/IndJPhaEdRes-56-2-405.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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| School of Pharmacy | School of Pharmacy | Archieval Section | 2022-08-29 | 2022-1424 | 2022-08-29 | 2022-08-29 | Articles Abstract Database |