Paira, Moumita
PPh3-Catalyzed Intramolecular Cyclization of hydroxypropargylamides: Synthesis of Structurally Diverse Morpholinone Derivatives - Vol.61(9), Sep - New Delhi CSIR 2022 - 1014-1024p.
The metal-free synthesis of functionalized morpholinones through a sequential intramolecular post-ugi cyclization strategy is described. In the subsequent step, Ugi adducts hydroxypropargylamides derivative undergoes chemo- and regioselective 6-exo-dig catalytic cyclization to afford O-cyclized product in the presence of triphenylphosphine. This sequence offers an engrossing functionalized morpholinones scaffolds involving moderate reaction conditions with broad substrate scopes and moderate to good yields.
GENERAL CHEMISTRY
PPh3-Catalyzed Intramolecular Cyclization of hydroxypropargylamides: Synthesis of Structurally Diverse Morpholinone Derivatives - Vol.61(9), Sep - New Delhi CSIR 2022 - 1014-1024p.
The metal-free synthesis of functionalized morpholinones through a sequential intramolecular post-ugi cyclization strategy is described. In the subsequent step, Ugi adducts hydroxypropargylamides derivative undergoes chemo- and regioselective 6-exo-dig catalytic cyclization to afford O-cyclized product in the presence of triphenylphosphine. This sequence offers an engrossing functionalized morpholinones scaffolds involving moderate reaction conditions with broad substrate scopes and moderate to good yields.
GENERAL CHEMISTRY