PPh3-Catalyzed Intramolecular Cyclization of hydroxypropargylamides: Synthesis of Structurally Diverse Morpholinone Derivatives
By: Paira, Moumita
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Publisher: New Delhi CSIR 2022Edition: Vol.61(9), Sep.Description: 1014-1024p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: The metal-free synthesis of functionalized morpholinones through a sequential intramolecular post-ugi cyclization strategy is described. In the subsequent step, Ugi adducts hydroxypropargylamides derivative undergoes chemo- and regioselective 6-exo-dig catalytic cyclization to afford O-cyclized product in the presence of triphenylphosphine. This sequence offers an engrossing functionalized morpholinones scaffolds involving moderate reaction conditions with broad substrate scopes and moderate to good yields.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2023-0809 |
Total holds: 0
The metal-free synthesis of functionalized morpholinones through a sequential intramolecular post-ugi cyclization strategy is described. In the subsequent step, Ugi adducts hydroxypropargylamides derivative undergoes chemo- and regioselective 6-exo-dig catalytic cyclization to afford O-cyclized product in the presence of triphenylphosphine. This sequence offers an engrossing functionalized morpholinones scaffolds involving moderate reaction conditions with broad substrate scopes and moderate to good yields.
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