Datchanamurthy, Barathane
Antinociceptive and anti-inflammatory activity of extract of acorus calamus rhizomes in experimental animal models - Vol.17(3), Jul-Sep - M P BRNSS Publication Hub. 2023 - 226-232p.
Background: Complex biological responses like inflammation are part and parcel of body’s immune system to
any noxious stimuli. Mediators released during inflammation irritate the free nerve endings which are perceived
by the body as pain. Hence, inflammation and pain often coexist and add up significant morbidity in humans.
Aims and Objectives: The aims and objectives of the study are to evaluate the antinociceptive and anti-inflammatory
activity of extract of Acorus calamus rhizomes in experimental animal models. Materials and Methods: Ethanolic
extract of A. calamus rhizomes was prepared by Soxhlet extraction. Inflammation, both acute and chronic, was
tested using carrageenan-induced paw edema and cotton pellet-induced granuloma model in rats whereas peripheral
and central anti-nociceptive activity was tested using acetic acid-induced writhing in mice and tail immersion test
in rats. Results: Significant reduction in writhing, paw edema volume, granuloma size, and increase in reaction
time with tail immersion was observed with the extract treated groups in a dose-dependent manner. standard drug
diclofenac was found to be better than the extract but failed to show significant difference with a higher dose of
the extract. Conclusion: The ethanolic extract of A. calamus rhizome possesses significant antinociceptive and
anti-inflammatory activity.
PHARMACEUTICS
Antinociceptive and anti-inflammatory activity of extract of acorus calamus rhizomes in experimental animal models - Vol.17(3), Jul-Sep - M P BRNSS Publication Hub. 2023 - 226-232p.
Background: Complex biological responses like inflammation are part and parcel of body’s immune system to
any noxious stimuli. Mediators released during inflammation irritate the free nerve endings which are perceived
by the body as pain. Hence, inflammation and pain often coexist and add up significant morbidity in humans.
Aims and Objectives: The aims and objectives of the study are to evaluate the antinociceptive and anti-inflammatory
activity of extract of Acorus calamus rhizomes in experimental animal models. Materials and Methods: Ethanolic
extract of A. calamus rhizomes was prepared by Soxhlet extraction. Inflammation, both acute and chronic, was
tested using carrageenan-induced paw edema and cotton pellet-induced granuloma model in rats whereas peripheral
and central anti-nociceptive activity was tested using acetic acid-induced writhing in mice and tail immersion test
in rats. Results: Significant reduction in writhing, paw edema volume, granuloma size, and increase in reaction
time with tail immersion was observed with the extract treated groups in a dose-dependent manner. standard drug
diclofenac was found to be better than the extract but failed to show significant difference with a higher dose of
the extract. Conclusion: The ethanolic extract of A. calamus rhizome possesses significant antinociceptive and
anti-inflammatory activity.
PHARMACEUTICS