Pawar, Shweta
Formulation and evaluation of garlic powder loaded floating matrix tablet - Vol. 2(3) - M P Innovare Academic Sciences Pvt Ltd 2019 - 17-21p.
Objective:
The objective of the present work was to formulate and evaluate a stable, odour
free garlic powder loaded floating matrix tablet for the
treatment of peptic ulcers.
Method
s:
A
gastro
-retentive
floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of
hydroxypropyl
methylcellulose
K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable
floati
ng time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet.
3
2
Result
s:
It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h
with FT
up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during
the
stability
study of FMT.
full factorial designs were used for selection of suitable polymer concentration and effervescent system. No
nenteric film coating was applied to
mask GP
odour
.
Conclusio
n:
A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formu
lation
can overcome problems of taste and odour
masking, gastric irritation, and loss of active constituents present in garlic.
PHARMACEUTICS
Formulation and evaluation of garlic powder loaded floating matrix tablet - Vol. 2(3) - M P Innovare Academic Sciences Pvt Ltd 2019 - 17-21p.
Objective:
The objective of the present work was to formulate and evaluate a stable, odour
free garlic powder loaded floating matrix tablet for the
treatment of peptic ulcers.
Method
s:
A
gastro
-retentive
floating matrix tablet (FMT) formulation of garlic powder (GP) was prepared using various concentrations of
hydroxypropyl
methylcellulose
K4M (HPMC K4 M) and effervescent system (sodium bicarbonate and citric acid in 1:1 % w/w) to achieve desirable
floati
ng time (FT), floating lag time (FLT) and drug release. Wet granulation method was selected using ethanol as a binder for preparation of tablet.
3
2
Result
s:
It was observed that FMT with optimum quantities of HPMC K4M and the effervescent system showed 97 % of drug release in 12 h
with FT
up to 10 h and minimum FLT of 3 min. There was no significant change in FLT, FT and drug content during
the
stability
study of FMT.
full factorial designs were used for selection of suitable polymer concentration and effervescent system. No
nenteric film coating was applied to
mask GP
odour
.
Conclusio
n:
A stable, sustained release FMT of GP tablets using HPMC K4M and an effervescent system was successfully prepared. This formu
lation
can overcome problems of taste and odour
masking, gastric irritation, and loss of active constituents present in garlic.
PHARMACEUTICS