Effect of partially hydrolyzed ginsenoside on in vitro Skin permeation and retention of collagen pentapeptide (palmitoyl-KTTKS) (Record no. 15810)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20211229105526.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 211229b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15187 |
| Author | Selvaraj, K. |
| 245 ## - TITLE STATEMENT | |
| Title | Effect of partially hydrolyzed ginsenoside on in vitro Skin permeation and retention of collagen pentapeptide (palmitoyl-KTTKS) |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol.83(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mumbai |
| Name of publisher, distributor, etc. | Indian Journal of Pharmaceutical Science |
| Year | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 76-83p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Although palmitoyllysine threonine threonine lysine serine is claimed to be a useful bioactive peptide molecule to arrest skin aging, literature on transdermal permeation and retention of the peptide has rarely been reported. Aim of this study was to investigate the effect of partially hydrolyzed ginsenoside on transdermal permeation and retention of palmitoyl lysine threonine threonine lysine serine loaded liquid crystalline nanoparticles. Palmitoyl lysine threonine threonine lysine serine was loaded onto liquid crystalline nanoparticles using a hot melting and sonication method. Particle size of the liquid crystalline nanoparticles was reduced to <300 nm after addition of partially hydrolyzed ginsenoside into the constitution of the liquid crystalline nanoparticles and the polydispersity index indicated a monodisperse state. Transmission electron microscopy showed multilayered spherical liquid crystalline nanoparticles with dense core and corona like surface. Franz diffusion cell study demonstrated that skin permeation of palmitoyl lysine threonine threonine lysine serine was significantly increased when loaded onto liquid crystalline nanoparticles comprising partially hydrolyzed ginsenoside (p<0.01), and that this was proportional to the amount of the ginsenoside added. The steady state flux of palmitoyl lysine threonine threonine lysine serine in liquid crystalline nanoparticles comprising 2.84 % ginsenoside increased 4.60 fold and 2.36 fold compared to that of control (solubilized in propylene glycol) and liquid crystalline nanoparticles without ginsenoside, respectively. Partially hydrolyzed ginsenoside may be useful as a novel material to improve skin permeation of peptide molecules suffering from low transdermal absorption. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 15188 |
| Co-Author | Shin, D. C. |
| 773 0# - HOST ITEM ENTRY | |
| Place, publisher, and date of publication | New Delhi |
| Title | Indian journal of pharmaceutical sciences |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://www.ijpsonline.com/articles/effect-of-partially-hydrolyzed-ginsenoside-on-emin-vitroem-skin-permeation-and-retention-of-collagen-pentapeptide-palmit.pdf |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2021-12-29 | 2021-2022627 | 2021-12-29 | 2021-12-29 | Articles Abstract Database |